2021 USCAP Maude Abbott Lecture - Neuroendocrine Carcinomas ntawm Lub taub hau thiab caj dab:
Yav dhau los, tam sim no thiab yav tom ntej ua tau

BRUCE M. WENIG, MD

Thawj Tswj Hwm thiab Senior Member
Department of Pathology
Moffitt Cancer Center
Professor ntawm Oncological Sciences
Tsev kawm ntawv ntawm South Florida
Tampa, Florida

Lub sijhawm ua haujlwm: 1 teev 26 feeb

COV TSWV YIM

Neuroendocrine neoplasms (NEN) tshwm sim hauv txhua lub cev. Txoj kev loj hlob ntawm embryologic ntawm NEN tau muaj kev sib cav txog seb puas muaj lossis tsis yog ib qho keeb kwm neural crest. Raws li lub hauv paus ntsiab lus ntawm cov keeb kwm neural crest, lub hav zoov ntawm ib txoj hauv kev biochemical nyob rau hauv cov hlwb neuroendocrine muaj xws li uptake thiab decarboxylation ntawm amine precursors tau postulated tso cai rau cov hlwb no tau txheeb xyuas histochemically thiab ua rau kev siv cov acronym APUD (Amine Precursor. Uptake thiab Decarboxylation) los piav txog cov hlwb hauv cov kab ke no. Cov kev tshawb fawb tom qab debunked ib hom neural crest keeb kwm thiab kev faib tawm Dispersed Neuroendocrine Cell System tau txais rau NEN. Kev faib tawm ntawm NEN tau dhau los ua ib qho kev hloov pauv uas tam sim no cov tswv yim tsis hais txog ntawm qhov chaw ntawm lub hauv paus chiv keeb tau tawm tswv yim siv cov npe tsim los rau plab hnyuv thiab pancreatic NEN. Ib cag ntawm txoj hnyuv, txiav thiab lub ntsws, thaj tsam lub taub hau thiab caj dab yog ib qho ntawm cov chaw uas tshwm sim ntau dua rau NEN thiab nyob rau hauv cheeb tsam no neuroendocrine carcinoma yog feem ntau hom ntawm qhov chaw tshwj xeeb NEN. Qhov kev hais lus no yuav tsom mus rau neuroendocrine carcinomas ntawm lub taub hau thiab caj dab tshuaj xyuas lawv cov yam ntxwv kho mob thiab sib tham txog lawv cov kev suav nrog hauv cov txheej txheem kev faib tawm tsis sib xws uas tau thov rau lwm qhov chaw tshwj xeeb NEN.

KAWM TAU TXAIS

1. Sib tham txog kev txhim kho embryologic ntawm neuroendocrine neoplasms
2. Piav qhia txog cov txheej txheem kuaj mob rau lub taub hau thiab caj dab neuroendocrine neoplasms sib piv cov qauv no rau lwm qhov chaw tshwj xeeb NEN
3. Txiav txim siab seb cov txheej txheem kev faib ua feem rau NEN puas siv tau rau lub taub hau thiab caj dab NEN